Assuming the bulk of your income comes from "earned income," your best bets are moves that lower your taxable income.

You say that some of your salary goes into a 401(k). The more you contribute to your 401(k), the less taxable income you have. In 2019 the maximum amount you can contribute is $19,000. In 2020 that number will go up to $19,500.

Other tax-advantaged investment opportunities are available as well. Your income is probably too high to deduct Traditional IRA contributions, but if you have a high-deductible insurance plan you can contribute up to $3,500 ($3,550 in 2020) to a [health savings account](https://www.investopedia.com/terms/h/hsa.asp). This money is saved pre-tax, grows tax-defered, and withdrawn tax-free if used for medical expenses. Otherwise, it can be withdrawn after retirement age just like a traditional retirement plan withdrawal. If you don't have a high-deductible plan or decide against an HSA for some other reason, an [FSA](https://www.investopedia.com/terms/f/flexiblespendingaccount.asp) could be another option to cover some healthcare expenses tax-free, but beware the "use-it-or-lose-it" rules.

Contributing to a [529 college savings plan](https://www.investopedia.com/terms/1/529-savings-plan.asp) doesn't provide any immediate lowering of federal income taxes, but it can reduce your state income taxes, depending on your state. This is a good idea if you think you might have children (or nieces/nephews or friends or yourself or whatever) someday whose college education you'd like to support. You must set a beneficiary for a 529 plan, but that beneficiary can be changed at a later date.

Finally, one of the biggest ways you can reduce your tax burden is by marrying someone who makes less money than you. You can than file a joint tax return. Having children could also entire you to some tax credits or deductions.