The amount I have in RRSP savings is exactly equal to the amount I have in Home Equity Line of Credit debt (significant, but aside from home mortgage, my family has no other debt).
I know if I cashed out the RRSPs, I would be taxed, but since I've just changed careers and now have a much lower income, I'm tempted to cash in my RRSPs to cover the bulk of my HELOC so it's no longer looming over me. Otherwise, it might take me forever to repay it.