Basically, no. You have retirement plan options and can either go with a Roth option, which won't change your current tax burden, or go with a traditional plan, which is tax deductible but won't change your business deductions or self-employment taxes. This article has an explanation of options for setting up SEP or Solo 401k plans. Key quote for all the pre-tax retirement plans:
Because pre-tax employer and employee contributions are deducted in
the same way, neither one is more tax-efficient than the other.
The article goes on to say that if you were an S Corp or LLC that elected to be taxed as an S Corp, a Solo 401(k) plan would allow the business to make an employer contribution to your 401(k) and even then there's no tax advantage to the employer contribution. Conclusion for S-corps:
[Employer contributions] would reduce the amount of income from the S-corporation that
would be passed through to you as the owner, thereby reducing your
income tax. But, because this income is not subject to payroll taxes
in the first place, these contributions will not reduce your payroll